منابع مشابه
Aging: T cell metabolism within tumors
incidence of cancer increases in the aged partially due to accumulations of genomic mutations, epigenetic dysregulations and the development of chronic inflammatory responses. In US, more than 50% of all cancer cases occur in patients over 65 [1]. Cancer immunotherapy, which has achieved significant breakthroughs in recent years, harnesses the patients' own immune system. However, the immune sy...
متن کاملRecent Advances in T Cell Signaling in Aging
The immune system of mammalian organisms undergoes alterations that may account for an increased susceptibility to certain infections, autoimmune diseases, or malignancies. Well characterized are age related defect in T cell functions and cell mediated immunity. Although it is well established that the functional properties of T cells decrease with age, its biochemical and molecular nature is...
متن کاملElevated potassium levels suppress T cell activation within tumors
Tumors progress in immunocompetent hosts despite the ability of the adaptive immune system to recognize cancer cells. Ion gradients regulate T cell function but their role in intratumoral immune responses is unexplored. We found that the concentration of K was strikingly elevated within tumors while the concentration of the divalent cations Ca and Mg was similar to serum levels. High K levels s...
متن کاملT cell aging
The immune system exhibits profound age-related changes, collectively termed immunosenescence. The most visible of these is the decline in protective immunity, which results from a complex interaction of primary immune defects and compensatory homeostatic mechanisms. The sum of these changes is a dysregulation of many processes that normally ensure optimal immune function. Recent advances sugge...
متن کاملrecent advances in t cell signaling in aging
the immune system of mammalian organisms undergoes alterations that may account for an increased susceptibility to certain infections, autoimmune diseases, or malignancies. well characterized are age related defect in t cell functions and cell mediated immunity. although it is well established that the functional properties of t cells decrease with age, its biochemical and molecular nature is p...
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ژورنال
عنوان ژورنال: Aging
سال: 2016
ISSN: 1945-4589
DOI: 10.18632/aging.100979